Denosumab (anti-RANK ligand)

Catalog No.A2020        Batch: A202003

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Technical Data

CAS No. 615258-40-7
Formulation PBS Buffer, pH 7.4
Isotype human IgG4
Source HEK293
Storage
(From the date of receipt)
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Purity 99.68%
Protein concentration 5mg/ml
Endotoxin Level <1EU/mg

Biological Activity

Description Denosumab (anti-RANK ligand) (AMG-162, Prolia, Xgeva) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM.

Selleck's Denosumab (anti-RANK ligand) has been cited by 1 publication

Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression [ ACS Omega, 2023, 8(23):20739-20754] PubMed: 37323396

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.