CA77.1

Catalog No.S6395 Batch:S639501

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Technical Data

Formula

C16H12ClN3O

Molecular Weight 297.74 CAS No. 2412270-22-3
Solubility (25°C)* In vitro DMSO 30 mg/mL (100.75 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).
Targets
CMA [1]
In vivo

CA77.1 activates CMA in vitro in dose- and time-dependent manner without affecting macroautophagy and when administering in vivo demonstrate brain penetrance with favorable pharmacokinetics, activation of CMA in brain of KFERQ-Dendra mice, and absence of blood or major organs toxicity after 3 months of daily treatment.[2]

Protocol (from reference)

Animal Study:

[2]

  • Animal Models

    Male wild-type mice (C57BL/6J)

  • Dosages

    10 mg/Kg or 1mg/Kg

  • Administration

    i.v.&p.o.

Selleck's CA77.1 has been cited by 1 publication

Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway [ Sci Adv, 2023, 9(40):eadi8343] PubMed: 37801503

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.