Bilibubin

Catalog No.S5116 Batch:S511601

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Technical Data

Formula

C33H36N4O6
Molecular Weight 584.66 CAS No. 635-65-4
Solubility (25°C)* In vitro DMSO 3 mg/mL (5.13 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.
In vitro As a potent antioxidant, bilirubin effectively blocks the generation of cellular reactive oxygen species induced by the cross-linking of endothelial vascular cell adhesion molecule 1 (VCAM‐1) or intercellular adhesion molecule 1 (ICAM-1)[1].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    Human umbilical vein endothelial cells (HUVECs)

  • Concentrations

    20 μmol/L

  • Incubation Time

    24 h

  • Method

    HUVEC monolayers are incubated with TNF-α (5 ng/mL) in the presence of bilirubin (BR; 20 μmol/L) or the bilirubin vehicle (Veh) for 24 hours, and protein levels of IL‐6, IL‐8, IL‐1β, MCP‐1, M‐CSF, and RANTES in cell-culture medium are determined.

Animal Study:[1]
  • Animal Models

    C57BL/6J mice

  • Dosages

    30 mg/kg

  • Administration

    i.p.

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.