Atorvastatin

Catalog No.S5715 Batch:S571503

Technical Data

Formula	C₃₃H₃₅FN₂O₅
Molecular Weight	558.64	CAS No.	134523-00-5
Solubility (25°C)*	In vitro	DMSO	100 mg/mL (179.0 mM)
		Ethanol	6 mg/mL (10.74 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.
In vitro	Atorvastatin, one of the statins, inhibits the c-Myc pathway in chronic myeloid leukemia (CML) cells, demonstrating that c-Myc is a target of statins.^[1]
In vivo	ATV-Exos activates AKT/eNOS signaling pathway to augment the angiogenesis of endothelial cells via upregulating miR-211-3p, thereby resulting in accelerated wound regeneration of the diabetic rats.^[2]

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines murine CML-KLS⁺ cells, OP-9 stromal cells Concentrations 2 μM Incubation Time 3 days Method CML cKit+Lineage Sca1+ (KLS) cells are isolated from CML mice. Thereafter, the effect of statins on the colony-forming capacity of CML-KLS cells is determined. Freshly isolated CML-KLS cells are co-cultured with OP-9 stromal cells in the presence of IM (1 M), DA (0.5 M), and rosuvastatin (2 M) or atorvastatin (2 M) for 72 h. Thereafter, the cells are washed with PBS and transferred to semi-solid medium. The number of colonies is counted under the microscope.
Animal Study:^{^[2]}	Animal Models Sprague-Dawley rats ofdiabetes models Dosages 50 μg/mL Administration s.c

Cell Assay:^{^[1]}

Cell lines
murine CML-KLS⁺ cells, OP-9 stromal cells
Concentrations
2 μM
Incubation Time
3 days
Method
CML cKit+Lineage Sca1+ (KLS) cells are isolated from CML mice. Thereafter, the effect of statins on the colony-forming capacity of CML-KLS cells is determined. Freshly isolated CML-KLS cells are co-cultured with OP-9 stromal cells in the presence of IM (1 M), DA (0.5 M), and rosuvastatin (2 M) or atorvastatin (2 M) for 72 h. Thereafter, the cells are washed with PBS and transferred to semi-solid medium. The number of colonies is counted under the microscope.

Animal Study:^{^[2]}

Animal Models
Sprague-Dawley rats ofdiabetes models
Dosages
50 μg/mL
Administration
s.c

References

Selleck's Atorvastatin has been cited by 23 publications

The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia [ Oncogene, 2024, 43(4):281-293]	PubMed: 38030791
Clinically conserved genomic subtypes of gastric adenocarcinoma [ Mol Cancer, 2023, 22(1):147]	PubMed: 37674200
Clinically conserved genomic subtypes of gastric adenocarcinoma [ Mol Cancer, 2023, 22(1):147]	PubMed: 37674200
RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence [ Oncogene, 2023, 42(21):1716-1727]	PubMed: 37029299
Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death [ Cells, 2023, 12(24)2836]	PubMed: 38132158
Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML [ Int J Mol Sci, 2023, 24(4)4235]	PubMed: 36835644
Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis [ Oncogene, 2022, 41(39):4446-4458]	PubMed: 36008464
In Vitro Evidence of Statins' Protective Role against COVID-19 Hallmarks [ Biomedicines, 2022, 10(9)2123]	PubMed: 36140223
In situ assessment of statins' effect on autophagic activity in zebrafish larvae cardiomyocytes [ Front Cardiovasc Med, 2022, 9:921829]	PubMed: 36465443
ANGIOTENSINOGEN UPTAKE and Stimulation of Oxidative Stress in Human Pigment Retinal Epithelial Cells [ Peptides, 2022, S0196-9781(22)00036-5]	PubMed: 35183655

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SHIPPING AND STORAGE
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