AST-1306

Catalog No.E0822 Batch:E082201

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Technical Data

Formula

C24H18ClFN4O2
Molecular Weight 448.88 CAS No. 897383-62-9
Solubility (25°C)* In vitro DMSO 85 mg/mL (189.36 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description AST-1306 (Allitinib) is an orally active and irreversible EGFR, ErbB2 and inhibitor with IC50s of 0.5, 3 and 0.8 nM, respectively.
Targets
EGFR [1] ErbB4 [1] ErbB2 [1]
0.5 nM 0.8 nM 3.0 nM

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/21789172/

Selleck's AST-1306 Has Been Cited by 12 Publications

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR-targeted therapies [ Mol Oncol, 2025, 10.1002/1878-0261.70096] PubMed: 40720248
RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR-targeted therapies [ Molecular Oncology, 2025, 3205-3222] PubMed: 40720248
Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line [ Human Cell, 2024, 1170-1183] PubMed: 38565739
Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in Obesity [ Cells, 2022, 425] PubMed: nan
Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines [ International Journal of Molecular Sciences, 2022, 7774] PubMed: 35887120
High ErbB3 activating activity in human blood is not due to circulating neuregulin-1 beta [ Life Sciences, 2020, 117634] PubMed: nan
LncRNA AFAP1-AS1 Supresses miR-139-5p and Promotes Cell Proliferation and Chemotherapy Resistance of Non-small Cell Lung Cancer by Competitively Upregulating RRM2 [ Frontiers in Oncology, 2019, 1103] PubMed: 31696057
Exploiting RKIP protein as a novel predictor of EGFR targeted therapies response in lung cancer [ University of Minho, 2019, ] PubMed: None
ErbB2 promotes endothelial phenotype of human left ventricular epicardial highly proliferative cells (eHiPC) [ Journal of Molecular and Cellular Cardiology, 2018, 39-50] PubMed: 29291395
ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway [ Oncology Reports, 2018, 2892-2898] PubMed: 29620274

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.