AR-C155858

Catalog No.S7919 Batch:S791901

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Technical Data

Formula

C21H27N5O5S
Molecular Weight 461.54 CAS No. 496791-37-8
Solubility (25°C)* In vitro DMSO 92 mg/mL (199.33 mM)
Ethanol 92 mg/mL (199.33 mM)
Water 8 mg/mL (17.33 mM)
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Ki value of 2.3 nM and 10 nM, respectively.
Targets
MCT1 [1] MCT2 [1]
2.3 nM(Ki) 10 nM(Ki)

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/19929853/

Selleck's AR-C155858 Has Been Cited by 9 Publications

Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression [ Redox Biology, May 25 2024, 103209] PubMed: 38861833
Environmental enrichment promotes functional recovery from stroke via enhancing neuroplasticity through the action of β-HB [ Journal of Cerebral Blood Flow & Metabolism, May 15 2025, 1918-1931] PubMed: 40370303
Insights into the physicochemical interactions of ionic liquid-coated polymeric nanoparticles with red blood cells [ Nanoscale Advances, July 11 2025, 5273-5283] PubMed: 40704282
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity [ Nature Communications, 2025, Article number: 1] PubMed: 41298379
Environmental enrichment promotes functional recovery from stroke via enhancing neuroplasticity through the action of β-HB [ J Cereb Blood Flow Metab, 2025, 0271678X251328179] PubMed: 40370303
Environmental enrichment promotes functional recovery from stroke via enhancing neuroplasticity through the action of β-HB [ Journal of Cerebral Blood Flow & Metabolism, 2025, 0271678X251328179] PubMed: 40370303
Insights into the physicochemical interactions of ionic liquid-coated polymeric nanoparticles with red blood cells [ Nanoscale Advances, 2025, 5273-5283] PubMed: 40704282
Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression [ Redox Biology, 2024, 103209] PubMed: 38861833
Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer [ bioRxiv, 2024, 10.1101/2024.01.25.577208] PubMed: none

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.