Anti-mouse CD3ε-InVivo [145-2C11]

Catalog No.A2104 Batch: A210408

Clone No.145-2C11

The 145-2C11 monoclonal antibody reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death.

Technical Data

Formulation	PBS buffer, pH 7.0
Clone	145-2C11
Immunogen	Mouse BM10-37 cytotoxic T cells
Isotype	Armenian Hamster IgG1
Application	in vitro T cell stimulation/activation, IF, FCM, WB
Source	CHO
Murine Pathogen Screening Panel	all targets tested yielded Negative Results: Theiler’s Murine Encephalomyelitis Virus, Ectromelia (Mousepox) Virus, Hantavirus, Polyomavirus, Sendai Virus, Mycoplasma pulmonis, Pneumonia Virus of Mice, K Virus, Mouse Parvovirus, Mouse Hepatitis Virus, Mouse Norovirus, Mouse Minute Virus, Mouse Cytomegalovirus, Mouse Adenovirus, Lactate Dehydrogenase-Elevating Virus, Reovirus Panel, Lymphocytic Choriomeningitis Virus, Mouse Rotavirus.
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Sterility	6.79 mg/mL
Purity	99%
Protein concentration	6.79 mg/mL
Endotoxin Level	＜1 EU/mg

Selleck's Anti-mouse CD3ε-InVivo [145-2C11] Has Been Cited by 16 publications

Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single-Cell Level [ Advanced Science, September 23, 2024, 11(43):e2310282]	https://www.ncbi.nlm.nih.gov/pubmed/?term=39308190
Near-infrared II fluorescence imaging of PD-L1 and VEGF for assessing and early prediction of “T+A” therapeutic responsiveness in hepatocellular carcinoma [ Materials Today Bio, June 1, 2026, 38:103228]	https://www.ncbi.nlm.nih.gov/pubmed/?term=42211064
Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity [ Experimental & Molecular Medicine, July 6, 2026, 1-15]	https://www.ncbi.nlm.nih.gov/pubmed/?term=42409961
Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity [ Experimental and Molecular Medicine, July 2026, nan]	https://www.ncbi.nlm.nih.gov/pubmed/?term=42409961
Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity [ Experimental and Molecular Medicine, July 2026, Online ahead of print]	https://www.ncbi.nlm.nih.gov/pubmed/?term=42409961
Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer [ Nature Communications, February 9, 2026, 17(1): 1-17]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41663394
Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer [ Nature Communications, February 9, 2026, 17(1):2526]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41663394
Short-term starvation inhibits CD36 N-glycosylation and downregulates USP7 UFMylation to alleviate RBPJ-maintained T cell exhaustion in liver cancer [ Theranostics, April 28, 2025, 15(12):5931-5952]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40365281
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma [ Cell Communication and Signaling, 2026-02-02, 155]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41629991
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma [ Cell Communication and Signaling, 2026, Online ahead of print]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41629991

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

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We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.