Alamandine

Catalog No.P1107 Batch:P110702

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Technical Data

Formula

C40H62N12O9
Molecular Weight 855 CAS No. 1176306-10-7
Solubility (25°C)* In vitro DMSO 100 mg/mL (116.95 mM)
Water 100 mg/mL (116.95 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Alamandine is a component of the renin-angiotensin system, which regulates blood pressure.
In vitro

Alamandine decreases leptin secretion and expression in isolated adipocytes mediated by Gq, c-Src, p38 mitogen-activated protein and IκB activation, also induces nitric oxide expression via inducible nitric oxidase synthase and plasminogen activator inhibitor 1 expression in isolated adipocytes.[2]
In vivo

Moderately concentrated alamandine reduces blood leptin levels in vivo.[2]
Density 95.0~105.0%

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    adipocytes isolated from rats, 3T3L-1 adipocytes

  • Concentrations

    0.01, 0.1, 1, 10, 100, 1000 nM

  • Incubation Time

    24 h

  • Method

    Isolated adipocytes are incubated with alamandine for 24 h. Secreted leptin levels are determined using a leptin immunoassay kit according to the manufacturer’s protocol.
Animal Study:

[2]
  • Animal Models

    Wistar rats (10-week-old)

  • Dosages

    576, 57.6, 5.76, or 0.576 µg/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.