AA26-9

Catalog No.S0286 Batch:S028601

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Technical Data

Formula

C7H10N4O
Molecular Weight 166.18 CAS No. 1312782-34-5
Solubility (25°C)* In vitro DMSO 33 mg/mL (198.57 mM)
Water 33 mg/mL (198.57 mM)
Ethanol 33 mg/mL (198.57 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description AA26-9 is a potent and broad spectrum inhibitor of Serine hydrolases (SHs).
Targets
SHs [1]
In vitro

A broadspectrum 1,2,3-triazole urea, AA26-9, inhibits about one-third of the more than 40 serine hydrolases found in T cells could be efficiently converted into compounds that potently and selectively inactivate individual serine hydrolases.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    BW5147-derived mouse T-cell hybridoma cells

  • Concentrations

    20 μM

  • Incubation Time

    4 h

  • Method

    Cells were cultured with 20 μM inhibitor for 4 h, lysed, separated into soluble and membrane proteomic fractions and analyzed by competitive gel-based ABPP.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.