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Technical Data
| Formula | C18H18O2 |
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| Molecular Weight | 266.334 | CAS No. | 35354-74-6 | |
| Solubility (25°C)* | In vitro | DMSO | 53 mg/mL (198.99 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. This compound causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. It inhibits hepatitis C virus (HCV) infection. Phase 3. | ||
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| Targets |
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| In vitro | Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. This compound is effective on inducing apoptosis in SVR angiosarcoma cells. Treatment of SVR cells with this chemical causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, it potentiates TRAIL-mediated apoptosis, and its cytotoxicity is partially abrogated by neutralizing antibodies to TRAIL. This compound also has direct antiangiogenic activity, in that it blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. [1] It causes apoptosis in CLL cells through activation of caspase 8, followed by caspase 9 and 3 activation. This chemical prevents interleukin-4-mediated survival of CLL cells, and potentiats the cytotoxicity of CB-1348, FaraA, and 2-CdA. [3] It kills myeloma cells from relapsed patients at doses that does not kill PBMCs. Caspase 3, 7, 8, and 9 are induced by this compound treatment, as well as PARP cleavage. [2] It is found to induce apoptosis in the colon cancer cell lines RKO. [4] This chemical potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. [5] It may act as a potent anti-inflammatory agent with multipotential activities due to an inhibitory effect on the PI3K/Akt pathway. [6] |
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| In vivo | Honokiol is highly effective against SVR angiosarcoma in nude mice. [1] This compound inhibits the growth of RKO cells in murine xenografts. [4] It prevents the growth of MDA-MD-231 breast cancer cells in murine xenografts. [7] |
Protocol (from reference)
References
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Customer Product Validation
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, , Front Pharmacol, 2017, 8:199
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Data from [ , , Front Pharmacol, 2018, 9:558 ]
Selleck's Honokiol Has Been Cited by 35 Publications
| Period3 modulates the NAD+-SIRT3 axis to alleviate depression-like behaviour by enhancing NAMPT activity in mice [ J Adv Res, 2025, S2090-1232(25)00062-1] | PubMed: 39894345 |
| Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation [ J Nanobiotechnology, 2025, 23(1):414] | PubMed: 40462120 |
| BDNF is a prognostic biomarker involved in the immune infiltration of lung adenocarcinoma and associated with programmed cell death [ Oncol Lett, 2025, 29(4):191] | PubMed: 40041412 |
| Honokiol inhibits human osteosarcoma MG63 cell migration by upregulating FTO and Smad6 to promote autophagy [ Mol Cell Probes, 2024, 78:101988] | PubMed: 39454801 |
| Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and Sperm Intracellular Calcium Influx [ Int J Nanomedicine, 2023, 18:4313-4327] | PubMed: 37576465 |
| Honokiol attenuates ductular reaction, regulates of bile acids metabolism, and inhibits inflammatory response in murine cholestatic liver injury model [ Arabian Journal of Chemistry , 2023, Volume 16, Issue 8] | PubMed: None |
| Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence [ Exp Gerontol, 2023, 173:112091] | PubMed: 36657533 |
| Sirt3 mediates the benefits of exercise on bone in aged mice [ Cell Death Differ, 2022, 10.1038/s41418-022-01053-5] | PubMed: 36153410 |
| Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission [ Br J Pharmacol, 2022, 10.1111/bph.15837] | PubMed: 35297042 |
| Magnesium Isoglycyrrhizinate Reduces the Target-Binding Amount of Cisplatin to Mitochondrial DNA and Renal Injury through SIRT3 [ Int J Mol Sci, 2022, 23(21)13093] | PubMed: 36361883 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.