Heparin sodium

Catalog No.S1346 Batch:S134606

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Technical Data

Formula

(C12H16NS2Na3)20

Molecular Weight CAS No. 9041-08-1
Solubility (25°C)* In vitro Water 100 mg/mL
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.
Targets
Antithrombin III [1]
In vitro

Heparin is widely used as an anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin and the structurally related heparan sulfate are complex linear polymers comprised of a mixture of chains of different length, having variable sequences. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin and heparan sulfate predominantly exhibit linear helical secondary structures with sulfo and carboxyl groups displayed at defined intervals and in defined orientations along the polysaccharide backbone. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization. [1]

Protocol (from reference)

Animal Study:

[3]

  • Animal Models

    C57BL/6J mice

  • Dosages

    100, 500, or 2500 units/kg

  • Administration

    i.p.

Selleck's Heparin sodium has been cited by 23 publications

Comparative assessment of embryotoxicity of 2,4,6-triiodophenol to mouse blastoid and pre-implantation embryo models [ Ecotoxicol Environ Saf, 2023, 252:114608] PubMed: 36738612
Exosome-transported circHDAC1_004 Promotes Proliferation, Migration, and Angiogenesis of Hepatocellular Carcinoma by the miR-361-3p/NACC1 Axis [ J Clin Transl Hepatol, 2023, 11(5):1079-1093] PubMed: 37577235
Protocol to develop a microfluidic human corneal barrier-on-a-chip to evaluate the corneal epithelial wound repair process [ STAR Protoc, 2023, 4(1):102122] PubMed: 36861830
Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart Tissues [ Adv Sci (Weinh), 2022, 9(30):e2203388] PubMed: 36055796
Chemical-Empowered Human Adipose-Derived Stem Cells with Lower Immunogenicity and Enhanced Pro-angiogenic Ability Promote Fast Tissue Regeneration [ Stem Cells Transl Med, 2022, 11(5):552-565] PubMed: 35511745
Spike-based adenovirus vectored COVID-19 vaccine does not aggravate heart damage after ischemic injury in mice [ Commun Biol, 2022, 5-1:902] PubMed: 36056135
Inhibition of Colon Cancer Recurrence via Exogenous TRAIL Delivery Using Gel-like Coacervate Microdroplets [ Gels, 2022, 8(7)427] PubMed: 35877512
Diacylglycerol, PKC and MAPK signaling initiate tubeworm metamorphosis in response to bacteria [ Dev Biol, 2022, 487:99-109] PubMed: 35500661
Coacervate-mediated novel pancreatic cancer drug Aleuria Aurantia lectin delivery for augmented anticancer therapy [ Biomater Res, 2022, 26(1):35] PubMed: 35869562
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS [ Nat Struct Mol Biol, 2021, 10.1038/s41594-020-00537-7] PubMed: 33398173

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.