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Technical Data
| Formula | C26H30FN7O3 |
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| Molecular Weight | 507.56 | CAS No. | 722544-51-6 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (197.02 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1. | ||
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| In vitro | Barasertib (AZD1152-HQPA), a highly selective Aurora B inhibitor, causes polyploidy and apoptosis in many cancer cell lines.[1] |
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| In vivo | Barasertib (AZD1152-HQPA) is an aurora B kinase inhibitor, and has efficacy against RB1 / SCLC cell line xenografts, RB1 / SCLC PDXs, and autochthonous Rb1 / neuroendocrine tumors.[1] |
Protocol (from reference)
| Cell Assay: |
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References
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Customer Product Validation
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Data from [Data independently produced by Nature, 2014, 508(7494), 118-22]
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Data from [Data independently produced by J Exp Med, 2014, 10.1084/jem.20141123]
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Data from [Oncogene, 2014, 33, 3550-60]
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Data from [Oncogene, 2012, 31, 1217–1227]
Selleck's Barasertib (AZD1152-HQPA) has been cited by 156 publications
| Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs [ Gastroenterology, 2024, S0016-5085(24)00062-3] | PubMed: 38262581 |
| Detection of senescence using machine learning algorithms based on nuclear features [ Nat Commun, 2024, 15(1):1041] | PubMed: 38310113 |
| Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells [ Br J Cancer, 2024, 10.1038/s41416-024-02584-z] | PubMed: 38287178 |
| Chromosomal passenger complex condensates generate parallel microtubule bundles in vitro [ J Biol Chem, 2024, S0021-9258(24)00045-0] | PubMed: 38272221 |
| Inhibition of epigenetic and cell cycle-related targets in glioblastoma cell lines reveals that onametostat reduces proliferation and viability in both normoxic and hypoxic conditions [ Sci Rep, 2024, 14(1):4303] | PubMed: 38383756 |
| Molecular landscape and functional characterization of centrosome amplification in ovarian cancer [ Nat Commun, 2023, 14(1):6505] | PubMed: 37845213 |
| Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis [ Nat Commun, 2023, 14(1):1680] | PubMed: 36973261 |
| Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation [ Haematologica, 2023, 108(9):2487-2502] | PubMed: 37021526 |
| Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation [ Haematologica, 2023, 108(9):2487-2502] | PubMed: 37021526 |
| Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment [ Cell Rep, 2023, 42(9):113098] | PubMed: 37714156 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.