EdU (5-Ethynyl-2'-deoxyuridine)

Catalog No.S1661 Batch:S166101

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Technical Data

Formula

C11H12N2O5
Molecular Weight 252.22 CAS No. 61135-33-9
Solubility (25°C)* In vitro DMSO 50 mg/mL (198.23 mM)
Water 17 mg/mL (67.4 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description EdU (5-Ethynyl-2'-deoxyuridine), a thymidine analogue, which can be incorporated into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction) are developed as a method for detection of DNA synthesis. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
In vivo

5-Ethynyl-2'-deoxyuridine (EdU, 5-EdU, 2'-Deoxy-5-ethynyluridine), a thymidine analogue developed for detection of DNA synthesis, the number of EdU positive cells in the dentate gyrus of the hippocampus (DG) were slightly increased in a dose dependent manner in voluntary exercise (running) mouse groups, while decreased in restraint stress mouse model significantly.[2]

Protocol (from reference)

Animal Study:

[2]
  • Animal Models

    Voluntary exercise mouse model, Restraint stress mouse model

  • Dosages

    10, 20, 50, 100 or 200 mg/kg

  • Administration

    i.p.

Selleck's EdU (5-Ethynyl-2'-deoxyuridine) has been cited by 1 publication

XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxyuridine [ Int J Mol Sci, 2022, 23(2)893] PubMed: 35055077

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.