Vanillyl Alcohol

Catalog No.S3859 Batch:S385901

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Technical Data

Formula

C8H10O3
Molecular Weight 154.16 CAS No. 498-00-0
Solubility (25°C)* In vitro DMSO 30 mg/mL (194.6 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol), derived from vanillin, is used to flavor food.
In vitro Vanillyl alcohol (VA) attenuates the elevation of reactive oxygen species (ROS) levels, decreases in the Bax/Bcl-2 ratio and poly (ADP-ribose) polymerase proteolysis. It protects dopaminergic MN9D cells against MPP+-induced apoptosis by relieving oxidative stress and modulating the apoptotic process[2]. VA has a suppressive effect on ferric chloride-induced lipid peroxidation in rat brains in vitro[3].
In vivo vanillyl alcohol possesses anti-angiogenic, anti-inflammatory, and anti-nociceptive activities. Vanillyl alcohol contains both anticonvulsive and suppressive effects on seizures and lipid peroxidation induced by ferric chloride in rats[1].

Protocol (from reference)

Cell Assay:[2]
  • Cell lines

    MN9D Cells

  • Concentrations

    1, 10, 20 μM

  • Incubation Time

    4 h

  • Method

    MN9D cells are pretreated with various concentrations (10, 100, 200 μg/mL) of GE and 1, 10, 20 μM vanillyl alcohol for 4 h before incubation in medium containing 25 μM MPP+. The control cells are treated with the same medium without drugs.
Animal Study:[1]
  • Animal Models

    Male ICR mice

  • Dosages

    3, 10, or 30 mg/kg

  • Administration

    oral

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.