UNC2881

Catalog No.S7325 Batch:S732501

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Technical Data

Formula

C25H33N7O2

Molecular Weight 463.58 CAS No. 1493764-08-1
Solubility (25°C)* In vitro DMSO 92 mg/mL (198.45 mM)
Ethanol 7 mg/mL (15.09 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.
Targets
Mer [1]
(Cell-free assay)
Tyro3 [1]
(Cell-free assay)
4.3 nM 250 nM
In vitro UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation. [1]
In vivo UNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice. [1]

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    Swiss albino mice

  • Dosages

    ~3 mg/kg

  • Administration

    i.v. or p.o.

Selleck's UNC2881 has been cited by 2 publications

Dead Cells Induce Innate Anergy via Mertk after Acute Viral Infection. [ Cell Rep, 2020, 30(11):3671-3681] PubMed: 32187540
Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia. [ Front Immunol, 2019, 10:2647] PubMed: 31781126

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.