Tyrosol

Catalog No.S3773 Batch:S377301

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Technical Data

Formula

C8H10O2
Molecular Weight 138.16 CAS No. 501-94-0
Solubility (25°C)* In vitro DMSO 27 mg/mL (195.42 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives. Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.
Targets
NF-κB [2]
In vitro

Tyrosol (Tyr) suppresses TNF-α-induced intracellular production of ROS, depletion of GSH, and down-regulation of genes encoding antioxidant enzymes in hECs. Tyr inhibits palmitic acid-induced oxidative stress in human liver HepG2 cells[1].
In vivo

After ingestion, Tyrosol (Tyr) undergoes extensive first pass intestinal/hepatic metabolism[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    hECs (human endothelial cells)

  • Concentrations

    0-200 μM

  • Incubation Time

    48 h

  • Method

    hECs are cultured in 96-well plates in eight replicate sets at a density of 104 cells per well in the presence of Tyr or its metabolites at the indicated concentrations for 48 h. Cell viability is assayed based on the ability of live cells to reduce methylthiazolyldiphenyl-tretrazolium bromide (MTT).
Animal Study:

[1]
  • Animal Models

    Swiss albino mice

  • Dosages

    0.5 mg/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.