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Technical Data
| Formula | C25H34N4O2S |
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| Molecular Weight | 454.63 | CAS No. | 1011557-82-6 | |
| Solubility (25°C)* | In vitro | DMSO | 98 mg/mL (215.55 mM) | |
| Water | 98 mg/mL (215.55 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2. | ||||||||||
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| Targets |
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| In vitro | Tenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and 67 μM, respectively. [1] |
Protocol (from reference)
References
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Selleck's Tenovin-6 has been cited by 5 publications
| SIRT1 and HSP90α feed-forward circuit safeguards chromosome segregation integrity in diffuse large B cell lymphomas [ Cell Death Dis, 2023, 14(10):667] | PubMed: 37816710 |
| p53 Deacetylation Alleviates Sepsis-Induced Acute Kidney Injury by Promoting Autophagy [ Front Immunol, 2021, 12:685523] | PubMed: 34335587 |
| SNRPB promotes cervical cancer progression through repressing p53 expression. [ Biomed Pharmacother, 2020, 125:109948] | PubMed: 32106364 |
| Arp2/3-branched actin regulates microtubule acetylation levels and affects mitochondrial distribution. [ J Cell Sci, 2019, 132(6)] | PubMed: 30782777 |
| Acetylation site specificities of lysine deacetylase inhibitors in human cells. [Scholz C, et al. Nat Biotechnol, 2015, 10.1038/nbt.3130] | PubMed: 25751058 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.