Tabersonine hydrochloride

Catalog No.S5101 Batch:S510103

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Technical Data

Formula

C21H24N2O2.HCl

Molecular Weight 372.89 CAS No. 29479-00-3
Solubility (25°C)* In vitro DMSO 75 mg/mL (201.13 mM)
Ethanol 25 mg/mL (67.04 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
Targets
Aβ(1−42) aggregation [1]
In vitro Tabersonine disrupts Aβ(1−42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. It binds to Aβ(1−42) oligomers more strongly than to Aβ(1−42) monomers with Kd values of 69 μM and 535 μM, respectively[1].
In vivo The biocompatibility and small size essential for permeating the blood−brain barrier make tabersonine a potential therapeutic drug candidate for treating Alzheimer's disease (AD)[1].

Protocol (from reference)

Cell Assay:

[1]

  • Cell lines

    SH-SY5Y cell

  • Concentrations

    10 μM

  • Incubation Time

    24 h

  • Method

    The cultured cells were transferred to a sterile 96-well plate with approximately 1×104 cells/well. Cells acclimatized overnight in the media in a humidified incubator under 5% CO2 at 37℃. Aβ(1−42)solutions and Aβ(1−42)−tabersonine mixtures were preincubated at 37℃ for different times, and the resultant solutions were mixed with the SH-SY5Y cells for 24 h. The viability of the SH-SY5Y cells exposed to each solution was determined with MTT assay. Cell viability was estimated by dividing the absorbance of wells containing samples by that of wells containing only cell culture media.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.