Sulfabenzamide

Catalog No.S4576 Batch:S457601

Technical Data

Formula	C₁₃H₁₂N₂O₃S
Molecular Weight	276.31	CAS No.	127-71-9
Solubility (25°C)*	In vitro	DMSO	55 mg/mL (199.05 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.
In vitro	Sulfabenzamide inhibits the proliferation and increases Caspase-3 activity in T-47D cells. It dose not induce apoptosis but a minimal shift from G1 to S and G2/M phases of the cell cycle^[1].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines T-47D breast cancer cells Concentrations 0-20 mM Incubation Time 24, 48 and 72 h Method The MTT assay is used to evaluate the viability of T-47D cells incubated with different concentrations of sulfabenzamide (0.0-20 mM) or doxorubicin (0.0-0.6 μM) after 24, 48 and 72 h.

References

[1] Raziye MOHAMMADPOUR, et al. Journal of Cell and Molecular Biology. 2012, 10(1): 41-54.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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