Solanesol (Nonaisoprenol)

Catalog No.S2360 Batch:S236001

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Technical Data

Formula

C45H74O
Molecular Weight 631.07 CAS No. 13190-97-1
Solubility (25°C)* In vitro DMSO 100 mg/mL (158.46 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
Targets
FAK [1]
In vitro Solanesol is widely used as an intermediate for the synthesis of ubiquinone drugs, such as coenzyme Q10 and vitamin K2 as well as Vitamin K and Vitamin E. It is known to possess activities like antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and anti-ulcer activities. Solanesol binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK)[1]. Solanesol upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction. Solanesol also inhibits LDH, AST, MDA and ROS level, but increases the GSH level and promotes tBHQ-mediated protective effects[2].

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    normal human hepatic cell L02

  • Concentrations

    10, 50, 100, 250, 500, 1000 μM

  • Incubation Time

    12 h

  • Method

    Cell viability is determined by MTT assays. Cells are seeded into 96-well plates (5 × 104 cells/well) 24 h before treatment. The cells are then treated with various concentrations of solanesol followed by incubating with 5 mg/ml of MTT working solution for 4 h at 37 °C. After being treated with 100 μL of DMSO to dissolve the crystals, the cells are detected under an Microplate Reader to measure the absorbance at 570 nm.
Animal Study:

[3]
  • Animal Models

    Male albino rats

  • Dosages

    0.2 g of gel containing solanesol (1 % w/v)

  • Administration

    applied to the plantar surface of the right hind paw by gently rubbing with the index finger

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.