Skatole

Catalog No.S4959 Batch:S495901

Technical Data

Formula	C₉H₉N
Molecular Weight	131.17	CAS No.	83-34-1
Solubility (25°C)*	In vitro	DMSO	26 mg/mL (198.21 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
In vivo	3MI causes pulmonary edema in goats, sheep, rats, and some strains of mice. Response to 3-methylindole (3MI) varies among species. Mice recover from 3MI-induced bronchiolar epithelial injury but sustain persistent olfactory mucosal injury with scarring and epithelial metaplasia. In contrast, 3MI induces obliterative bronchiolitis in horses and ponies. It also causes severe olfactory mucosal damage and fibrosis in rodents (in addition to small airways disease)^[2].

Description

Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

In vivo

3MI causes pulmonary edema in goats, sheep, rats, and some strains of mice. Response to 3-methylindole (3MI) varies among species. Mice recover from 3MI-induced bronchiolar epithelial injury but sustain persistent olfactory mucosal injury with scarring and epithelial metaplasia. In contrast, 3MI induces obliterative bronchiolitis in horses and ponies. It also causes severe olfactory mucosal damage and fibrosis in rodents (in addition to small airways disease)^[2].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines Pig hepatocytes Concentrations 0.5 mM Incubation Time 24 h Method Cells were pre-incubated for 24 h prior to addition of acetone or skatole. A total of 17 mM acetone or 0.5 mM skatole (final concentration) were added and cells were incubated for further 24 h. Control cells were treated similarly except that no acetone or skatole was added.
Animal Study:^{^[2]}	Animal Models Fifteen adult grade ponies (aged 2 to approximately 20 years; mean weight, 177.1 kg) Dosages 100 mg/kg Administration nasogastric intubation

References

Selleck's Skatole has been cited by 2 publications

Natural Product Skatole Ameliorates Lipotoxicity-Induced Multiple Hepatic Damage under Hyperlipidemic Conditions in Hepatocytes [ Nutrients, 2023, 15(6)1490]	PubMed: 36986221
Activation of PGRN/MAPK axis stimulated by the hypoxia-conditioned mesenchymal stem cell-derived HIF-1α facilitates osteosarcoma progression [ Exp Cell Res, 2022, 421(1):113373]	PubMed: 36183781

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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