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Formula | C29H27F5N2O5S |
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Molecular Weight | 610.59 | CAS No. | 1456632-40-8 | |
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (163.77 mM) | |
Ethanol | 100 mg/mL (163.77 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. | ||||
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Targets |
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In vitro | SH-4-54 shows unprecedented cytotoxicity in human glioblastoma brain cancer stem cells (BTSCs), while has no toxicity in human fetal astrocytes. In addition, SH-4-54 effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets. [1] | ||||
In vivo | In mice orthotopically xenografted with BT73, SH-4-54 (10 mg/kg i.p.) exhibits BBB permeability, potently suppresses glioma tumor growth, and inhibits pSTAT3. [1] |
Kinase Assay: |
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Cell Assay: |
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Animal Study: |
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Data from [Data independently produced by , , Diabetologia, 2015, 58: 2064–2073]
Data from [Data independently produced by , , Sci Rep, 2016, 6:33358.]
Data from [Data independently produced by , , Biochim Biophys Acta, 2015, 1852(12):2671-7]
Data from [Data independently produced by , , J Infect, 2016, 72(3):338-52.]
BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4+ T-cell exhaustion [ Nat Commun, 2024, 15(1):1835] | PubMed: 38418488 |
JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States [ Cancer Res, 2023, 83(2):264-284] | PubMed: 36409824 |
Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans [ JCI Insight, 2023, 8(22)e164672] | PubMed: 37856221 |
CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: An improved preclinical model for research on mastocytosis [ Front Immunol, 2023, 14:1078958] | PubMed: 37025992 |
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis [ Theranostics, 2022, 12(10):4606-4628] | PubMed: 35832091 |
Blockade of STAT3/IL-4 overcomes EGFR T790M-cis-L792F-induced resistance to osimertinib via suppressing M2 macrophages polarization [ EBioMedicine, 2022, 83:104200] | PubMed: 35932642 |
BCL6 inhibition ameliorates ruxolitinib resistance in CRLF2-rearranged acute lymphoblastic leukemia [ Haematologica, 2022, 10.3324/haematol.2022.280879] | PubMed: 36005560 |
UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling [ Cell Death Dis, 2022, 13(5):424] | PubMed: 35501324 |
Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake [ Oncogene, 2022, 10.1038/s41388-022-02519-z] | PubMed: 36376513 |
Granulocytic myeloid-derived suppressor cells increase infection risk via the IDO/IL-10 pathway in patients with hepatitis B virus-related liver failure [ Front Immunol, 2022, 13:966514] | PubMed: 36685516 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.