Serotonin (5-HT) HCl

Catalog No.S4244 Batch:S424406

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Technical Data

Formula

C10H12N2O.HCl
Molecular Weight 212.68 CAS No. 153-98-0
Solubility (25°C)* In vitro DMSO 43 mg/mL (202.18 mM)
Water 43 mg/mL (202.18 mM)
Ethanol 43 mg/mL (202.18 mM)
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
2.1mg/ml Taking the 1 mL working solution as an example, add 50 μL of 42 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil
0.53mg/ml Taking the 1 mL working solution as an example, add 50 μL of 10.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Serotonin (5-HT) HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
Targets
5-HT [1]
In vitro Serotonin stimulates acid–base transport by the anterior stomach region of the midgut in vitro. The function of this stimulation is assumed to be maintenance of optimal conditions for digestion and absorption of nutrients rather than regulation of hemolymph acid–base homeostasis. [1]
In vivo The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition is investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. [1]

Protocol (from reference)

Selleck's Serotonin (5-HT) HCl has been cited by 7 publications

Immunophenotypic and molecular characterization of pancreatic neuroendocrine tumors producing serotonin [ Mod Pathol, 2022, 10.1038/s41379-022-01110-x] PubMed: 35739266
Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex [ Med Sci Sports Exerc, 2022, 54(4):566-581] PubMed: 34935710
Increasing serotonin concentrations alter calcium metabolism in periparturient dairy goats [ J Anim Sci, 2022, skac065] PubMed: 35235945
Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer [ Theranostics, 2021, 11(14):6950-6965] PubMed: 34093864
Role of 5-HT degradation in acute liver injury induced by carbon tetrachloride [ Eur J Pharmacol, 2021, 908:174355] PubMed: 34280394
Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines [ Sci Rep, 2021, 11(1):1250] PubMed: 33441923
Relationship between fatigue caused by type 2 diabetes mellitus and 5-HT degradation in skeletal muscle [ Acta Pharmaceutica Sinica, 2021, 56(1): 190-200] PubMed: None

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.