Rosavin

Catalog No.S3844 Batch:S384401

Technical Data

Formula	C₂₀H₂₈O₁₀
Molecular Weight	428.43	CAS No.	84954-92-7
Solubility (25°C)*	In vitro	DMSO	85 mg/mL (198.39 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities.
In vivo	Rosavin is eliminated in vivo quickly. T_1/2z for i.v. is 2.1 ± 0.5 h. T_max for p.o. is 0.9 ± 0.6 h, which indicates that the concentration of rosavin reached Cmax and it is fast absorbed in vivo ∼ 50 min after oral administration. Vz/F for i.v. is 17.6 ± 5.8 L/kg, which demonstrates that most of rosavin is distributed in extracellular fluid. CLz for p.o. is 93.8 ± 65.6 L/h/kg, which shows that rosavin experiences a slow elimination in vivo after oral administration. AUC_(0−∞) for p.o. is only 850.1 ± 766.1 μg/L h, and Vz/F for p.o. is much larger than that of i.v., which may be caused by highly water-soluble, polar and lower oil-water partition coefficient of rosavin, leading to the difficult absorption of the drug in vivo. Furthermore, rosavin is one of the glycoside compounds, which will be quiet easily hydrolyzed to aglycone in an acidic environment. The oral bioavailability is 4.7%. It may result from the poor membrane permeability, significant first-pass metabolism and efflux vector of small intestine and so on^[1].

Description

Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities.

In vivo

Rosavin is eliminated in vivo quickly. T_1/2z for i.v. is 2.1 ± 0.5 h. T_max for p.o. is 0.9 ± 0.6 h, which indicates that the concentration of rosavin reached Cmax and it is fast absorbed in vivo ∼ 50 min after oral administration. Vz/F for i.v. is 17.6 ± 5.8 L/kg, which demonstrates that most of rosavin is distributed in extracellular fluid. CLz for p.o. is 93.8 ± 65.6 L/h/kg, which shows that rosavin experiences a slow elimination in vivo after oral administration. AUC_(0−∞) for p.o. is only 850.1 ± 766.1 μg/L h, and Vz/F for p.o. is much larger than that of i.v., which may be caused by highly water-soluble, polar and lower oil-water partition coefficient of rosavin, leading to the difficult absorption of the drug in vivo. Furthermore, rosavin is one of the glycoside compounds, which will be quiet easily hydrolyzed to aglycone in an acidic environment. The oral bioavailability is 4.7%. It may result from the poor membrane permeability, significant first-pass metabolism and efflux vector of small intestine and so on^[1].

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models SD rats Dosages 10 mg/kg (i.v) and 50 mg/kg (oral administration) Administration i.v. and oral administration

References

[1] Chen D, et al. J Chromatogr Sci. 2016, 54(7):1166-70.

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SHIPPING AND STORAGE
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