ReACp53

Catalog No.S8187 Batch:S818702

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Technical Data

Formula

C108H206N52O24

Molecular Weight 2617.13 CAS No. unknown
Solubility (25°C)* In vitro Water 24 mg/mL (9.17 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
Targets
p53 amyloid formation [1]
In vitro

ReACp53 rescues p53 transcription of target genes and restores apoptosis. Rescued p53 behaves similarly to its wild-type counterpart in regulating target genes, reducing cell proliferation and increasing cell death[1].

In vivo

ReACp53 halts progression and shrinks tumors bearing aggregation-prone p53[1].

Protocol (from reference)

Cell Assay:

[1]

  • Cell lines

    S1 GODL cells

  • Concentrations

    5 μM

  • Incubation Time

    16 h

  • Method

    Cells were treated with various concentrations of drug for 16 h.

Selleck's ReACp53 has been cited by 1 publication

Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis [ PNAS Nexus, 2022, 1(3):pgac128] PubMed: 36741442

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.