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Technical Data
| Formula | C14H18Cl2N2O |
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| Molecular Weight | 301.21 | CAS No. | 123464-89-1 | |
| Solubility (25°C)* | In vitro | DMSO | 46 mg/mL (152.71 mM) | |
| Water | 11 mg/mL (36.51 mM) | |||
| Ethanol | 4 mg/mL (13.27 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with Ki value of 26 nM for the rat receptor. | ||||
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| Targets |
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| In vitro | PNU282987 shows high affinity for the rat α7 nAChR (Ki = 26 nM) and activity at the α7-5-HT3 chimera (EC50 = 128 nM) and showed a negligible block of α1β1γδ and α3β4 nAChRs (≥60 μM). It is inactive at all tested monoamine, muscarine, glutamate, and GABA receptors at 1 μM concentration, except 5-HT3 receptors (Ki = 930 nM). PNU-282987 enhances GABAergic synaptic activity in the hippocampus in vitro[1]. | ||||
| In vivo | PNU-282987 reverses amphetamine-induced gating deficit in amphetamine-treated rats[1]. |
Protocol (from reference)
| Animal Study: |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.