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Technical Data
| Formula | C35H41ClN6O4 |
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| Molecular Weight | 645.19 | CAS No. | 1538593-71-3 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (154.99 mM) | |
| Ethanol | 100 mg/mL (154.99 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death. |
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| In vitro | Piperazine Erastin, an analogue of Erastin, induces ferroptosis of cancer cells and upregulates PTGS2 in BJeLR cells that is suppressed when cotreatment of vitamin E.[1] |
| In vivo | Piperazine Erastin shows efficacy in preventing HT-1080 tumor formation in a mouse xenograft model, through upregulation of Ptgs2, and robust upregulation of the p21 gene, a biomarker for p53 activation induced by doxorubicin-mediated DNA damage.[1] |
Protocol (from reference)
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.