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Technical Data
| Formula | C50H68F2N6O4.C4H6O6 |
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| Molecular Weight | 1005.2 | CAS No. | 706782-28-7 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (99.48 mM) | |
| Water | 50 mg/mL (49.74 mM) | |||
| Ethanol | 3 mg/mL (2.98 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease. | ||
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| In vivo | In rats, Pimavanserin (3 mg/kg, p.o.) attenuates DOI-induced head twitches. In mice, Pimavanserin (3 mg/kg, p.o.) significantly attenuates MK-801-induced hyperactivity. [1] In a rat model of parkinsonian tremor, Pimavanserin (40 mg/kg, i.p.) produces a significant overall reduction of tacrine-induced tremulous jaw movements. [2] |
Protocol (from reference)
| Animal Study: |
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References
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Selleck's Pimavanserin tartrate has been cited by 3 publications
| A new class of serotonin 5-HT2A /5-HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2-aminotetralins [ Br J Pharmacol, 2021, 10.1111/bph.15756] | PubMed: 34837227 |
| Repurposing Pimavanserin, an Anti-Parkinson Drug for Pancreatic Cancer Therapy [ Mol Ther Oncolytics, 2020, 19:19-32] | PubMed: 33024816 |
| Discovery of Procognitive Antipsychotics by Combining Muscarinic M1 Receptor Structure-Activity Relationship with Systems Response Profiles in Zebrafish Larvae [ ACS Chem Neurosci, 2020, 11(2):173-183] | PubMed: 31850734 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.