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Technical Data
| Formula | C22H21F3N6O3S |
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| Molecular Weight | 506.5 | CAS No. | 717906-29-1 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (197.43 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively. | ||||
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| Targets |
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| In vitro | In A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phosphorylation of Pyk2 and FAK, and further blocks B cell spreading. [2] PF-431396 consistently inhibits the increase in protein tyrosine phosphorylation (PY) induced by the absence of added calcium and induced by W-7 in the presence of calcium. [3] |
Protocol (from reference)
References
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Selleck's PF-431396 has been cited by 11 publications
| Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia [ Nat Commun, 2023, 14(1):6270] | PubMed: 37805579 |
| Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells [ Cell Rep, 2023, 42(5):112529] | PubMed: 37200193 |
| Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects [ J Exp Clin Cancer Res, 2021, 40(1):364] | PubMed: 34784956 |
| SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase [ Cancers (Basel), 2021, 13(24)6344] | PubMed: 34944965 |
| A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction [ Nat Commun, 2020, 11(1):3282] | PubMed: 32612176 |
| Myeloid cells provide critical support for T-ALL in vivo [ The University of Texas at Austin, 2020, ] | PubMed: None |
| Inositol polyphosphate multikinase is a metformin target that regulates cell migration [ FASEB J, 2019, 33(12):14137-14146] | PubMed: 31657647 |
| Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma. [ Cancer Biol Ther, 2018, 19(4):316-327] | PubMed: 29303405 |
| Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. [ Mol Cell, 2017, 67(3):512-527] | PubMed: 28757207 |
| Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders. [ J Immunol, 2017, 198(5):2082-2092] | PubMed: 28087670 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.