Pentoxifylline

Catalog No.S4345 Batch:S434501

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Technical Data

Formula

C13H18N4O3

Molecular Weight 278.31 CAS No. 6493-05-6
Solubility (25°C)* In vitro DMSO 55 mg/mL (197.62 mM)
Water 55 mg/mL (197.62 mM)
Ethanol 55 mg/mL (197.62 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.
In vitro Pentoxifylline exhibits synergism with CDDP in killing MCF-7/E6 cells but does not affect sensitivity of the control cells. Pentoxifylline inhibits G2 checkpoint function to a greater extent in MCF-7/E6 than in the parental cells. [1] Pentoxifylline acts primarily by increasing red blood cell deformability, by reducing blood viscosity and by decreasing the potential for platelet aggregation and thrombus formation. [2] Pentoxifylline is efficacious in suppressing LPS-induced MO-derived TNF at the level of both TNF mRNA accumulation and TNF supernatant bioactivity. Pentoxifylline (10 μM) suppresses the production of both biologically active TNF and TNF mRNA expression by more than 50% in LM cells. [3] Pentoxifylline blocks cachectin/TNF mRNA accumulation but has no effect upon the efficiency of reporter mRNA translation in RAW 264.7 macrophages. Pentoxifylline combined with Dexamethasone causes a greater suppression of cachectin/TNF biosynthesis that can be achieved by either agent alone in RAW 264.7 macrophages. [4]
In vivo Pentoxifylline (500 mg) markedly inhibits increases in the serum levels of TNF and IL-6, as well as the effects on coagulation and fibrinolysis, in chimpanzees. Pentoxifylline (500 mg) along with Endotoxin (4 ng/kg) also has a significant effect on thrombin generation in chimpanzees. [5]

Protocol (from reference)

Selleck's Pentoxifylline has been cited by 2 publications

Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable [ Antiviral Res, 2023, 216:105674] PubMed: 37459896
Repurposing FDA-approved drugs for anti-aging therapies. [ Biogerontology, 2016, 17(5-6):907-920] PubMed: 27484416

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.