Paromomycin Sulfate

Catalog No.S4183 Batch:S418301

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Technical Data

Formula

C23H45N5O14.xH2SO4

Molecular Weight 713.71 CAS No. 1263-89-4
Solubility (25°C)* In vitro Water 100 mg/mL (140.11 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Paromomycin Sulfate(Aminosidine sulfate) is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.
Targets
16S ribosomal RNA [1]
In vitro

Paromomycin is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. [1] In vitro analysis on the sensitivity of amastigotes in a murine macrophage model showed that L. major and L. tropica isolates (ED50s in the range of 1 to 5 μM) are more sensitive than L. braziliensis (ED50, <12 μM) and L. mexicana (ED50, 39 μM) isolates. L. donovani shows intermediate sensitivity (ED50, 6 to 18 μM), except for one Indian strain, DD8, which had an ED50 of >150 μM. [2]

In vivo

In both experimental models and clinical cases of CL, lesions caused by L. major treated with paromomycin ointment resolved faster and more completely than lesions caused by L. amazonensis and L. panamensis. [2]

Protocol (from reference)

Selleck's Paromomycin Sulfate has been cited by 1 publication

Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs [ Biomed Chromatogr, 2022, e5519.] PubMed: 36208186

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.