NSC348884

Catalog No.S8149 Batch:S814902

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Technical Data

Formula

C38H40N10

Molecular Weight 636.79 CAS No. 81624-55-7
Solubility (25°C)* In vitro DMSO 100 mg/mL (157.03 mM)
Ethanol 100 mg/mL (157.03 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.
Targets
nucleophosmin [1]
(In Granta cells)
nucleophosmin [1]
(In LNCaP cells)
1.7 μM 4 μM
In vitro NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. It disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53 and induces apoptosis[1].
In vivo In vivo invasion and intravasation (that is, the number of CTCs) are significantly inhibited after injection of NSC348884(as an inhibitor of NPM1 oligomerization) into the tumor-bearing mice. No significant difference in overall cell death is observed by histology in the treated tumors with the 4-hour brief treatments, suggesting that the inhibition seen is specific to migration.[2].

Protocol (from reference)

Animal Study:

[2]

  • Animal Models

    Mice bearing either orthotopic MDA-MB-231-GFP tumors (MDA231) or patient-derived HT17 and HT19 tumors

  • Dosages

    25 mg/kg

  • Administration

    i.p.

Selleck's NSC348884 has been cited by 4 publications

NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer. [ Nat Commun, 2020, 3;11(1):1669] PubMed: 32245950
Nucleolar protein NPM1 is essential for circovirus replication by binding to viral capsid [ Virulence, 2020, 11(1):1379-1393] PubMed: 33073687
Nucleolar stress regulates stromal-epithelial transition via NPM1 during decidualization [ Reproduction, 2020, 160(4):491-500] PubMed: 32817586
Nucleolar stress regulation of endometrial receptivity in mouse models and human cell lines. [ Cell Death Dis, 2019, 10(11):831] PubMed: 31685803

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.