NQDI-1

Catalog No.S8289 Batch:S828901

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Technical Data

Formula

C19H13NO4
Molecular Weight 319.31 CAS No. 175026-96-7
Solubility (25°C)* In vitro DMSO 21 mg/mL (65.76 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
0.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 10 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.
Targets
ASK1 [3]
(Cell-free assay)
3 μM
In vivo NQDI 1 inhibits the expression of ASK1 and downstream targets in the HI model. It also inhibits injury and apoptosis in the brain cortex. Intracerebroventricularly injection of NQDI 1 after neonatal rats brain HI significantly attenuates acute HI cerebral injury by inhibiting cell apoptosis. The treatment of NQDI-1 markedly inhibits the expression of ASK1 following HI in the perinatal rat, accompanied by a decrease of p-JNK, p-c-Jun, p53 and caspase 3, which were the downstream targets of ASK1[1].

Protocol (from reference)

Animal Study:

[1]
  • Animal Models

    Female Sprague-Dawley rats

  • Dosages

    250 nmol

  • Administration

    intracerebroventricularly

Selleck's NQDI-1 has been cited by 10 publications

FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response [ Redox Biol, 2023, 60:102618] PubMed: 36724577
Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway [ J Neuroinflammation, 2023, 20(1):22] PubMed: 36737785
ASK1 inhibitor NQDI‑1 decreases oxidative stress and neuroapoptosis via the ASK1/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in rats [ Mol Med Rep, 2023, 27(2)47] PubMed: 36633130
NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma [ Cell Death Dis, 2022, 13(3):197] PubMed: 35236820
A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells [ Arterioscler Thromb Vasc Biol, 2022, 42(5):580-596] PubMed: 35387478
Chronic-plus-binge Alcohol Intake Induces Production of Proinflammatory mtDNA-enriched Extracellular Vesicles and Steatohepatitis via ASK1-p38MAPKα-dependent Mechanisms [ JCI Insight, 2020, 136496] PubMed: 32544093
Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain. [ J Neuroinflammation, 2019, 16(1):83] PubMed: 30975172
The NEDD4-1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma. [ Int J Cancer, 2019, 10.1002/ijc.32615] PubMed: 31390487
Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen [Wang X J Steroid Biochem Mol Biol, 2019, 187:166-173] PubMed: 30508644
ASK1 induces retinal microvascular endothelial cell apoptosis through ER stress-associated pathway [ Int J Clin Exp Pathol, 2019, 12(4):1324-1332] PubMed: 31933946

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.