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Technical Data
| Formula | C15H12O5 |
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| Molecular Weight | 272.25 | CAS No. | 480-41-1 | |
| Solubility (25°C)* | In vitro | DMSO | 54 mg/mL (198.34 mM) | |
| Ethanol | 5 mg/mL (18.36 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. | |
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| Targets |
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| In vitro | Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless substances. [1] | |
| In vivo | Intragastrically administered Naringenin (50 mg/kg) induces a significant decrease in plasma glucose in normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models. LD50: Mice >5g/kg; Rats >5g/kg. [2] |
Protocol (from reference)
References
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Customer Product Validation
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Data from [Data independently produced by , , Scientific Reports 6, 2016, Article number: 27268 ]
Selleck's Naringenin has been cited by 11 publications
| Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity [ J Transl Med, 2024, 22(1):208] | PubMed: 38413989 |
| Synergism Antiproliferative Effects of Apigenin and Naringenin in NSCLC Cells [ Molecules, 2023, 28(13)4947] | PubMed: 37446609 |
| Network-Based Pharmacology and Bioinformatics Study on the Mechanism of Action of Gujiansan in the Treatment of Steroid-Induced Avascular Necrosis of the Femoral Head [ Biomed Res Int, 2022, 2022:8080679] | PubMed: 35915795 |
| Naringenin alleviates obesity-associated hypertension by reducing hyperlipidemia and oxidative stress [ Kidney Blood Press Res, 2022, 10.1159/000524172] | PubMed: 35354142 |
| Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors [ Int J Mol Sci, 2020, 21(14):5025] | PubMed: 32708687 |
| Aloperine inhibits hepatitis C virus entry into cells by disturbing internalisation from endocytosis to the membrane fusion process [ Eur J Pharmacol, 2020, 173323] | PubMed: 32622669 |
| An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
| Naringenin ameliorates insulin resistance by modulating endoplasmic reticulum stress in hepatitis C virus-infected liver. [ Biomed Pharmacother, 2019, 115:108848] | PubMed: 31039496 |
| Naringenin improve hepatitis C virus infection induced insulin resistance by increase PTEN expression via p53-dependent manner. [ Biomed Pharmacother, 2018, 103:746-754] | PubMed: 29684853 |
| A Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes. [Qian XJ, et al. Sci Rep, 2016, 6:27268] | PubMed: 27252043 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.