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Technical Data
| Formula | C21H27N7O14P2 |
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| Molecular Weight | 663.43 | CAS No. | 53-84-9 | |
| Solubility (25°C)* | In vitro | Water | 50 mg/mL (75.36 mM) | |
| DMSO | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. |
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| In vitro | NAD+, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage, modulates T cell function by regulating cellular energy metabolism.[1] |
Protocol (from reference)
| Cell Assay: |
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Selleck's NAD+ has been cited by 6 publications
| Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models [ Nat Commun, 2022, 13(1):7335] | PubMed: 36443325 |
| A phytobacterial TIR domain effector manipulates NAD+ to promote virulence [ New Phytol, 2022, 233(2):890-904] | PubMed: 34657283 |
| LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity [ Cell Rep, 2021, 37(8):110038] | PubMed: 34818543 |
| NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells [ Cell Rep, 2021, 36(6):109516] | PubMed: 34380043 |
| SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma [ Neoplasia, 2021, 23(1):129-139] | PubMed: 33316537 |
| Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys [ Mol Ther Nucleic Acids, 2016, 5:e319] | PubMed: 27164023 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.