Monocrotaline

Catalog No.S3812 Batch:S381203

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Technical Data

Formula

C16H23NO6

Molecular Weight 325.36 CAS No. 315-22-0
Solubility (25°C)* In vitro DMSO 63 mg/mL (193.63 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Monocrotaline (MCT, Crotaline) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale.

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    Male rats of the SD strain

  • Dosages

    60 mg/kg

  • Administration

    s.c.

Selleck's Monocrotaline has been cited by 1 publication

NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy [ Clin Sci (Lond), 2019, 133(9):1085-1096] PubMed: 31040165

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.