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Technical Data
| Formula | C29H25N3O4S |
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| Molecular Weight | 511.59 | CAS No. | 846557-71-9 | |
| Solubility (25°C)* | In vitro | DMSO | 20 mg/mL (39.09 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins. | ||||
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| In vitro | ML385 shows anti-tumor activity in NSCLC (subcutaneous and orthotopic NSCLC models) both as a single agent and in combination with NSC 241240. The PK profile tested in CD-1 mice shows that ML385 has a half-life (t1/2 = 2.82 h) after IP injection (30 mg/kg)[1]. ML385 could alleviate the pancreatic injury[2]. |
Protocol (from reference)
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References
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Selleck's ML385 has been cited by 111 publications
| IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1 [ Int J Biol Sci, 2024, 20(6):2323-2338] | PubMed: 38617533 |
| Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway [ Cell Death Discov, 2024, 10(1):35] | PubMed: 38238299 |
| Hydrophobic Components in Light-Yellow Pulp Sweet Potato (Ipomoea batatas (L.) Lam.) Tubers Suppress LPS-Induced Inflammatory Responses in RAW264.7 Cells via Activation of the Nrf2 Pathway [ Nutrients, 2024, 16(4)563] | PubMed: 38398887 |
| Propranolol Promotes Monocyte-to-Macrophage Differentiation and Enhances Macrophage Anti-Inflammatory and Antioxidant Activities by NRF2 Activation [ Int J Mol Sci, 2024, 25(7)3683] | PubMed: 38612493 |
| Rhizoma Paridis saponins attenuate Gram-negative bacteria-induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways [ J Cell Mol Med, 2024, 28(6):e18146] | PubMed: 38426932 |
| Electroacupuncture suppresses neuronal ferroptosis to relieve chronic neuropathic pain [ J Cell Mol Med, 2024, 28(7):e18240] | PubMed: 38509741 |
| Cardioprotective effects of asiaticoside against diabetic cardiomyopathy: Activation of the AMPK/Nrf2 pathway [ J Cell Mol Med, 2024, 28(2):e18055] | PubMed: 38113341 |
| Protective effects of triptolide against oxidative stress in retinal pigment epithelium cells via the PI3K/AKT/Nrf2 pathway: a network pharmacological method and experimental validation [ Aging (Albany NY), 2024, 16(4):3955-3972] | PubMed: 38393691 |
| Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway [ Eur J Pharmacol, 2024, 963:176264] | PubMed: 38123006 |
| NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin [ Chin Med, 2024, 19(1):60] | PubMed: 38589903 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.