Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Formula | C38H47O7PS |
|||
Molecular Weight | 678.81 | CAS No. | 845959-50-4 | |
Solubility (25°C)* | In vitro | DMSO | 50 mg/mL (73.65 mM) | |
Water | 10 mg/mL (14.73 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid. | ||
---|---|---|---|
Targets |
|
||
In vitro | Mitoquinone blocks H2O2-induced intracellular ROS responses inmurine pancreatic acinar cells. Mitoquinone does not reduce mitochondrial depolarisation induced by either cholecystokinin (CCK) or bile acid TLCS. Mitoquinone increases basal and CCK-induced cell death in a plate-reader assay.[1] |
||
In vivo | In a TLCS-induced AP model Mitoquinone treatment is not protective. In AP induced by caerulein hyperstimulation (CER-AP), Mitoquinone exerts mixed effects. Thus, partial amelioration of histopathology scores is observed but without reduction of the biochemical markers pancreatic trypsin or serumamylase. Lungmyeloperoxidase and interleukin-6 are concurrently increased by Mitoquinone in CER-AP. Mitoquinone causes biphasic effects on ROS production in isolated polymorphonuclear leukocytes, inhibiting an acute increase but elevating later levels.[1] |
Cell Assay: |
|
---|---|
Animal Study: |
|
Local production of reactive oxygen species drives vincristine-induced axon degeneration [ Cell Death Dis, 2023, 14(12):807] | PubMed: 38065950 |
O-GlcNAcylation Is Required for the Survival of Cerebellar Purkinje Cells by Inhibiting ROS Generation [ Antioxidants (Basel), 2023, 12(4)806] | PubMed: 37107182 |
Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis [ iScience, 2023, 26(9):107647] | PubMed: 37694150 |
MitoQ Protects Ovarian Organoids against Oxidative Stress during Oogenesis and Folliculogenesis In Vitro [ Int J Mol Sci, 2023, 24(2)924] | PubMed: 36674435 |
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling [ Immunity, 2022, S1074-7613(22)00280-1] | PubMed: 35835107 |
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis [ Immunity, 2022, 55(7):1185-1199.e8] | PubMed: 35738281 |
HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation [ J Exp Clin Cancer Res, 2022, 41(1):83] | PubMed: 35241126 |
Benchmarking AlphaFold-enabled molecular docking predictions for antibiotic discovery [ Mol Syst Biol, 2022, 18(9):e11081] | PubMed: 36065847 |
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype [ Cell Rep, 2022, 41-2:111462] | PubMed: 36223740 |
Loss of legumain induces premature senescence and mediates aging-related renal fibrosis [ Aging Cell, 2022, 21(3):e13574] | PubMed: 35195326 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.