|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Technical Data
| Formula | C15H18N4O5 |
|||
| Molecular Weight | 334.37 | CAS No. | 50-07-7 | |
| Solubility (25°C)* | In vitro | DMSO | 66 mg/mL (197.38 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
||||
Preparing Stock Solutions
Biological Activity
| Description | Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. | |
|---|---|---|
| Targets |
|
|
| In vitro | Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. [1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. [2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity. [3] |
|
| In vivo | As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth. [4] |
Protocol (from reference)
| Cell Assay: |
|
|---|---|
| Animal Study: |
|
References
Customer Product Validation
-
Data from [Data independently produced by , , Cancer Sci, 2018, 109(11):3450-3460]
Selleck's Mitomycin C has been cited by 114 publications
| Identifying squalene epoxidase as a metabolic vulnerability in high-risk osteosarcoma using an artificial intelligence-derived prognostic index [ Clin Transl Med, 2024, 14(2):e1586] | PubMed: 38372422 |
| Culture and expansion of murine proximal airway basal stem cells [ Stem Cell Res Ther, 2024, 15(1):26] | PubMed: 38287366 |
| Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy [ Burns Trauma, 2024, 12:tkad058] | PubMed: 38250706 |
| Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application [ Cell Rep Med, 2023, 10.1016/j.xcrm.2023.101277] | PubMed: 37944531 |
| PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR+ CXC chemokine expression [ EMBO Mol Med, 2023, 15(1):e16373] | PubMed: 36511116 |
| PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR+ CXC chemokine expression [ EMBO Mol Med, 2023, 15(1):e16373] | PubMed: 36511116 |
| Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis [ Cell Rep, 2023, 42(8):112944] | PubMed: 37566545 |
| Demethylating therapy increases cytotoxicity of CD44v6 CAR-T cells against acute myeloid leukemia [ Front Immunol, 2023, 14:1145441] | PubMed: 37180104 |
| T-cell dysfunction in natural killer/T-cell lymphoma [ Oncoimmunology, 2023, 12(1):2212532] | PubMed: 37250921 |
| Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma [ Biol Proced Online, 2023, 25(1):31] | PubMed: 38036976 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.