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Formula | C4H11N5 |
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Molecular Weight | 129.16 | CAS No. | 657-24-9 | |
Solubility (25°C)* | In vitro | DMSO | 26 mg/mL (201.3 mM) | |
Water | 26 mg/mL (201.3 mM) | |||
Ethanol | 26 mg/mL (201.3 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153. | |||
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In vitro | Metformin upregulates BAX activation with facilitation of BIM, BAD and PUMA, downregulates Bcl-2 and Bcl-xl, also induces cytochrome c release from mitochondria into the cytoplasm, directly triggering caspase-9-mediated mitochondrial apoptosis.[4] |
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In vivo | Metformin shows therapeutic effect of metformin in mouse model of liver fibrosis associated with nonalcoholic steatohepatitis (NASH) in which hepatic function, NASH lesions and fibrosis are improved.[4] |
Cell Assay: |
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Animal Study: |
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Pump-Less, Recirculating Organ-On-Chip (rOoC) Platform To Model The Metabolic Crosstalk Between Islets and Liver [ Adv Healthc Mater, 2024, e2303785.] | PubMed: 38221504 |
A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease [ Kidney Int, 2023, 103(5):917-929] | PubMed: 36804411 |
Metformin suppresses cardiac fibroblast proliferation under high-glucose conditions via regulating the mitochondrial complex I protein Grim-19 involved in the Sirt1/Stat3 signaling pathway [ Free Radic Biol Med, 2023, 206:1-12] | PubMed: 37353174 |
AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes [ J Orthop Translat, 2023, 38:158-166] | PubMed: 36439631 |
Resistin secreted by porcine alveolar macrophages leads to endothelial cell dysfunction during Haemophilus parasuis infection [ Virulence, 2023, 14(1):2171636] | PubMed: 36694280 |
Resveratrol Upregulates Senescence Marker Protein 30 by Activating AMPK/Sirt1-Foxo1 Signals and Attenuating H2O2-Induced Damage in FAO Rat Liver Cells [ J Nutr Sci Vitaminol (Tokyo), 2023, 10.3177/jnsv.69.388] | PubMed: 37940580 |
The NCF1 variant p.R90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells [ The Journal of Clinical Investigation, 2022-, 132(16)] | PubMed: None |
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia [ Cancer Cell, 2022, S1535-6108(22)00312-9] | PubMed: 35868306 |
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis [ EMBO Mol Med, 2022, 14(12):e16082] | PubMed: 36321555 |
Hepatic Leptin Signaling Improves Hyperglycemia by Stimulating MAPK Phosphatase-3 Protein Degradation via STAT3 [ Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00168-0] | PubMed: 35863745 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.