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Technical Data
| Formula | C20 H16 N2 O S |
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| Molecular Weight | 332.42 | CAS No. | 312917-14-9 | |
| Solubility (25°C)* | In vitro | DMSO | 20 mg/mL (60.16 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | JNK inhibitor IX (TCS JNK 5a) is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. | ||||
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| In vitro | JNK inhibitor IX significantly reduces caspase-3 activity by the inhibition of JNK activity in human dermal fibroblasts. [2] JNK inhibition by JNK inhibitor IX significantly increases apoptotic death in response to imatinib mesylate (IM) by preventing c-ABL complete de-phosphorylation at Ser residues. [3] |
Protocol (from reference)
References
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Customer Product Validation
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Data from [Data independently produced by , , Tumor Biol, 2016, 37:3135–3144.]
Selleck's JNK Inhibitor IX has been cited by 9 publications
| A subpopulation of CD146+ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome [ Cell Mol Immunol, 2023, 20(8):908-923] | PubMed: 37308559 |
| Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner [ Nat Commun, 2023, 14(1):3364] | PubMed: 37291128 |
| Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance. [ Nat Commun, 2020, 11(1):258] | PubMed: 31937753 |
| Targeting JNK pathway promotes human hematopoietic stem cell expansion. [ Cell Discov, 2019, 5:2] | PubMed: 30622738 |
| Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length. [ Elife, 2018, 7] | PubMed: 29595474 |
| Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway [ Front Immunol, 2017, 8:2011] | PubMed: 29403485 |
| Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells. [Zhou C, et al. Tumour Biol, 2016, 37(3):3135-44] | PubMed: 26427664 |
| Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal. [ Stem Cell Reports, 2015, 4(3):489-502] | PubMed: 25684228 |
| ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration [ PLoS Genet, 2015, 11(10):e1005595] | PubMed: 26496642 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.