JNJ-632

Catalog No.S0796 Batch:S079601

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Technical Data

Formula

C18H19FN2O4S

Molecular Weight 378.42 CAS No. 1572510-42-9
Solubility (25°C)* In vitro DMSO 76 mg/mL (200.83 mM)
Ethanol 76 mg/mL (200.83 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description JNJ-632 is a potent hepatitis B virus (HBV) capsid assembly modulator (CAM) with mean EC50 of 121 nM in HepG2.2.15 cells.
Targets
HBV capsid [1]
(in HepG2.2.15 cells)
121 nM(EC50)
In vitro

JNJ-632 shows similar anti-HBV activities across all four genotypes tested, with the EC50s for genotypes A to D being 101, 240, 119, and 200 nM, respectively, by preventing formation of covalently closed circular DNA in a dose-dependent fashion.[2]

In vivo

JNJ-632, a N-phenyl-3-sulfamoyl-benzamide derivative and HBV capsid assembly modulator, can inhibit HBV in vivo (HBV infected humanized mice) resulting in a 2.77 log reduction of HBV DNA viral load.[3]

Protocol (from reference)

Cell Assay:

[2]

  • Cell lines

    HBV (genotype A- to D)-infected primary human hepatocytes derived from naive chimeric mice

  • Concentrations

    --

  • Incubation Time

    4 days

  • Method

    Cells were cultured in RPMI 1640 medium supplemented with 2% FBS and incubated for 4 days at 37 ℃ in a 5% CO2 atmosphere in the presence or absence of serially diluted (1:4) JNJ-632. The cytotoxicity of the JNJ-632 was measured using the resazurin readout, and EC50 and EC90 values were calculated.

Animal Study:

[3]

  • Animal Models

    HBV Genotype D Infected Chimeric Mice

  • Dosages

    200 mg/kg/day

  • Administration

    s.c.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.