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Technical Data
| Formula | C17H13N3O |
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| Molecular Weight | 275.3 | CAS No. | 504433-23-2 | |
| Solubility (25°C)* | In vitro | DMSO | 25 mg/mL (90.81 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis. | ||
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| In vitro | GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. GW441756 can block TrkA-mediated γH2AX production[2]and apoptosis in TrkA-overexpressing cells. [3] |
Protocol (from reference)
| Animal Study: |
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References
Customer Product Validation
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Data from [Data independently produced by , , Exp Neurol, 2018, 300:87-99]
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Data from [Data independently produced by , , Mol Cell Neurosci, 2016, 77:11-20.]
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Data from [Data independently produced by , , Int J Mol Med, 2018, 42(3):1484-1494]
Selleck's GW441756 has been cited by 19 publications
| Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA [ Cells, 2023, 12(3)373] | PubMed: 36766714 |
| Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA. Cells 2023, 12, 373 [ Cells, 2023, 12(3):373] | PubMed: None |
| The effect of Banxia-houpo decoction on CUMS-induced depression by promoting M2 microglia polarization via TrkA/Akt signalling [ J Cell Mol Med, 2023, 10.1111/jcmm.17906] | PubMed: 37581474 |
| Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [ Front Mol Neurosci, 2023, 16:1214150] | PubMed: 37609072 |
| Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [ Front Mol Neurosci, 2023, 16:1214150] | PubMed: 37609072 |
| Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs [ Mediators Inflamm, 2023, 2023:4436587] | PubMed: 36860203 |
| Propionibacterium acnes contributes to low back pain via upregulation of NGF in TLR2-NF-κB/JNK or ROS pathway [ Microbes Infect, 2022, S1286-4579(22)00050-8] | PubMed: 35430372 |
| Sea urchin gangliosides exhibit neuritogenic effects in neuronal PC12 cells via TrkA- and TrkB-related pathways [ Biosci Biotechnol Biochem, 2021, 85(3):675-686] | PubMed: 33589896 |
| Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. [ Theranostics, 2020, 10(4):1649-1677] | PubMed: 32042328 |
| Activation of receptor tyrosine kinases mediates acquired resistance to MEK inhibition in malignant peripheral nerve sheath tumors [ Cancer Res, 2020, canres.1992.2020] | PubMed: 33203698 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.