Genz-123346 free base

Catalog No.S6496 Batch:S649602

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Technical Data

Formula

C24H38N2O4

Molecular Weight 418.57 CAS No. 491833-30-8
Solubility (25°C)* In vitro DMSO 84 mg/mL (200.68 mM)
Ethanol 84 mg/mL (200.68 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.
Targets
GL1 synthase [1]
In vivo

In Zucker diabetic fatty rats, treatment with Genz-123346 significantly lowers blood glucose levels and consequently partially prevents the normal deterioration of pancreatic β-cell function over time and preserves the ability of the islets to secrete insulin. In the high-fat-fed diet-induced obese mice, Genz-123346 essentially normalizes A1C levels to that of the lean animals. The improvement in A1C levels is quite persistent, extending >4 months in the diet-induced obese mice[1].

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    Zucker diabetic fatty rat

  • Dosages

    75, 85 and 125 mg/kg

  • Administration

    oral

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.