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Technical Data
| Formula | C22H28F2O5 |
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| Molecular Weight | 410.45 | CAS No. | 2135-17-3 | |
| Solubility (25°C)* | In vitro | DMSO | 82 mg/mL (199.78 mM) | |
| Ethanol | 6 mg/mL (14.61 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. | |
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| In vivo | Flumethasone (0.5 mg/100 kg b.w.) reduces insulin-dependent glucose utilization in calves at 24 hours after treatment. [1] Flumethasone combined with sodium ceftiofur reduces the mortality rate in calves with severe acute bronchopneumonia and their clinical and haematological parameters returns to normal significantly faster than in the control calves. [2] Flumethasone (5 mg) has a significant effect on recovery of uterine disease in cattle with ketosis. Flumethasone (5 mg) increases plasma glucose concentration and decreases serum beta-hydroxybutyric acid and urine acetoacetate concentrations following treatment in cattle with ketosis. [3] The Flumethasone level in the treated animals is generally above the detection limit although, in most cases, the concentration of Flumethasone is lower than the corresponding glucocorticoid level in the dexamethasone-exposed calves. Flumethasone is also detectable in the accompanying urine samples in calves. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. [4] |
Protocol (from reference)
References
Selleck's Flumethasone has been cited by 2 publications
| linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells [ Elife, 2023, 12e82249] | PubMed: 37191016 |
| High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction [ Drug Test Anal, 2020, 10.1002/dta.2917] | PubMed: 32852861 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.