Erythromycin Ethylsuccinate

Catalog No.S4060 Batch:S406001

Technical Data

Formula	C₄₃H₇₅NO₁₆
Molecular Weight	862.05	CAS No.	1264-62-6
Solubility (25°C)*	In vitro	DMSO	172 mg/mL (199.52 mM)
		Ethanol	172 mg/mL (199.52 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.
In vitro	Erythromycin displays antibacterial activity against Staphylococcus aureus, streptococcus pneumonia, Streptococcus pyogenes, Haemophilus influenza, Moraxella catarrhalis, Bordetella pertussis, Neisseria gonorrhoeae, Campylobacter jejuni, Helicobacter pylori, and Borrelia burgdorferi. ^[1] Erythromycin is a motilin receptor agonist, which is a potent stimulator of gastrointestinal motor activity. The concentrations of Erythromycin required to induce 50% of the maximum contractile response to a supramaximal dose of acetylcholine is 2 μM. The concentrations of Erythromycin required to displace 50% of the labeled motilin is 13 μM. Erythromycin has no effect on muscle strips of rat or dog duodenum but induces contractions in human strips. ^[2]

Description

Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.

In vitro

Erythromycin displays antibacterial activity against Staphylococcus aureus, streptococcus pneumonia, Streptococcus pyogenes, Haemophilus influenza, Moraxella catarrhalis, Bordetella pertussis, Neisseria gonorrhoeae, Campylobacter jejuni, Helicobacter pylori, and Borrelia burgdorferi. ^[1] Erythromycin is a motilin receptor agonist, which is a potent stimulator of gastrointestinal motor activity. The concentrations of Erythromycin required to induce 50% of the maximum contractile response to a supramaximal dose of acetylcholine is 2 μM. The concentrations of Erythromycin required to displace 50% of the labeled motilin is 13 μM. Erythromycin has no effect on muscle strips of rat or dog duodenum but induces contractions in human strips. ^[2]

Protocol (from reference)

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.