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Technical Data
| Formula | C40H37N5O |
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| Molecular Weight | 603.75 | CAS No. | 1440898-61-2 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (165.63 mM) | |
| Ethanol | 100 mg/mL (165.63 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ. | ||||
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| Targets |
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| In vitro | In liver cells, Deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by Deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. [1] | ||||
| In vivo | Deltarasin (10 mg/kg i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts. [1] |
Protocol (from reference)
| Animal Study:[1] |
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Selleck's Deltarasin has been cited by 6 publications
| Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements [ Eur J Cell Biol, 2023, 102(2):151314] | PubMed: 37058825 |
| MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells. [ Cell Death Differ, 2019, 26(11):2400-2415] | PubMed: 30833665 |
| EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells. [ Acta Pharmacol Sin, 2019, 10.1038/s41401-019-0268-y] | PubMed: 31316177 |
| Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion. [ Nat Commun, 2018, 9(1):672] | PubMed: 29445180 |
| Myeloid-derived interleukin-1β drives oncogenicKRAS-NF-κΒ addiction in malignant pleural effusion [ Nature Communications, 2018, 672-2018)] | PubMed: None |
| Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity [ Cell Death Dis, 2018, 9(2):216] | PubMed: 29440631 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.