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Technical Data
| Formula | C9H13N3O5.HCl |
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| Molecular Weight | 279.68 | CAS No. | 69-74-9 | |
| Solubility (25°C)* | In vitro | DMSO | 55 mg/mL (196.65 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. |
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Protocol (from reference)
Selleck's Cytarabine hydrochloride has been cited by 21 publications
| Acquired mutations in BAX confer resistance to BH3-mimetic therapy in Acute Myeloid Leukemia [ Blood, 2022, blood.2022016090] | PubMed: 36219880 |
| EEF2K silencing inhibits tumour progression through repressing SPP1 and synergises with BET inhibitors in melanoma [ Clin Transl Med, 2022, 12(2):e722] | PubMed: 35184394 |
| Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation [ Front Pharmacol, 2022, 13:1032975] | PubMed: 36313330 |
| The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML [ Blood Cancer J, 2021, 11(6):111] | PubMed: 34099621 |
| Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy [ Leukemia, 2021, 10.1038/s41375-021-01361-8] | PubMed: 34341479 |
| Downregulation of microRNA-9-5p promotes synaptic remodeling in the chronic phase after traumatic brain injury [ Cell Death Dis, 2021, 12(1):9] | PubMed: 33414448 |
| Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions [ J Cell Mol Med, 2021, 25(24):11039-11052] | PubMed: 34791807 |
| Receptor Activator of NF-κB (RANK) Confers Resistance to Chemotherapy in AML and Associates with Dismal Disease Course [ Cancers (Basel), 2021, 13(23)6122] | PubMed: 34885231 |
| Hydroxyurea-induced membrane fluidity decreasing as a characterization of neuronal membrane aging in Alzheimer's disease [ Aging (Albany NY), 2021, 13(9):12817-12832] | PubMed: 33972461 |
| High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia [ Transl Oncol, 2021, 14(5):101048] | PubMed: 33667892 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.