Citral

Catalog No.S5138 Batch:S513801

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Technical Data

Formula

C10H16O
Molecular Weight 152.23 CAS No. 5392-40-5
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil.
Density 0.888 g/mL at 25 °C

Biological Activity

Description Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil.
In vitro Citral is the mixture of two isomeric acyclic monoterpene aldehydes, the trans-isomer geranial or citral A and the cis-isomer neral or citral B. Several pharmacological activities of citral have been documented such as anti-inflammatory effects, antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi, and some protozoa, and anticancer activities against some cancer cell lines including leukemic, breast, and lymphoma cells. Treatment with citral results in an activation of caspase-3, leading to apoptosis in human U937, HL60, and NB4 and mouse RL12 and BS-24-1 leukemic cell lines. Moreover, it inhibits human breast cancer cell MCF-7 growth and induces cycle arrest in G2/M phase. Citral induces human lymphoma Ramos cell apoptosis by activating caspase activity in a concentration and time-dependent manner but has no effect on cell distribution in the cell cycle[1].
In vivo Citral can block the L-type calcium channels and shows a significant anti-inflammatory effect in the carrageenan model. It has a very important anti-inflammatory activity in the test of croton oil-induced ear edema in mice[2]. Treatment with citral oil in mice with lung injury induced by LPS inhibits TNF-α, IL-1β, and IL-6 levels both in vivo and in vitro[3].
Density 0.888 g/mL at 25 °C

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    Ramos and PBMCs

  • Concentrations

    10, 20, and 40 μM

  • Incubation Time

    24 h

  • Method

    Ramos and PBMCs (1 × 106 cells/ml) are also treated with doxorubicin in combination with citral (10, 20, and 40 µM) for 24 h at 37 °C. Cytotoxicity of treated cells is determined by adding 5 µl of 1 mg/ml resazurin solution in each well.
Animal Study:

[2]
  • Animal Models

    Virgin female Wistar rats aged 7-9 weeks

  • Dosages

    100-800 mg/kg

  • Administration

    oral

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.