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Formula | C10H16 |
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Molecular Weight | 136.23 | CAS No. | 138-86-3 | |
Solubility (25°C)* | In vitro | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Cinene (Limonene, Dipentene) is a clear, colorless liquid hydrocarbon classified as a cyclic monoterpene, and is the major component in oil of citrus fruit peels. It is usually used to make fragrances and flavors.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
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In vitro | Cinene (Limonene, Dipentene) treatment significantly elevates collagen synthesis, alkaline phosphatase activity, osteocalcin synthesis, and mineralization in osteoblastic cells. Limonene decreases interleukin (IL)-1 β-induced NF-κB, JNK and p38 activation and the expression of inflammatory (iNOS) and catabolic (MMP-1 and MMP-13) genes, while increasing the activation of anti-catabolic genes (TIMP-1) and ERK1/2 relative to IL-1β-treated cells in a cellular model of osteoarthritis. Limonene effectively protectes human lymphatic endothelial cells from H2O2-induced oxidative stress, and that its antioxidant effect is significant, increasing cell survival rate[1]. Limonene could inhibit LPS-induced production of nitric oxide, prostaglandin E2, and proinflammatory cytokines in RAW264.7 macrophages[2]. |
In vivo | In a mouse model of acute lung injury, limonene pretreatment at doses of 25, 50, and 75 mg/kg decreases LPS-induced evident lung histopathological changes, lung wet-to-dry weight ratio, and lung myeloperoxidase activity. In addition, pretreatment with limonene inhibits in flammatory cells and proin flammatory cytokines including tumor necrosis factor-α, interleukin-1β, and interleukin-6 in BALF (bronchoalveolar lavage fluid). Limonene blocks the phosphorylation of IκBα, nuclear factor-κB (NF-κB) p65, p38 mitogen-activated protein kinase (MAPK), c-Jun NH2-terminal kinase, and extracellular signal-regulated kinase in LPS-induced acute lung injury. It improves the pulmonary functions[2]. |
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RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.